Requirement for translocon-associated protein (TRAP) α in insulin biogenesis
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چکیده
منابع مشابه
TRAP builds a better translocon
In This Issue In This Issue TRAP builds a better translocon or over a decade, mechanistic studies of protein translocation into the mammalian ER have relied on proteoliposomes with translocons reconstituted from purified components, a system that efficiently translocates simple model proteins like prolactin, but often fails to match in vivo translo-cation efficiency for other substrates. On pag...
متن کاملDissecting the molecular organization of the translocon-associated protein complex
In eukaryotic cells, one-third of all proteins must be transported across or inserted into the endoplasmic reticulum (ER) membrane by the ER protein translocon. The translocon-associated protein (TRAP) complex is an integral component of the translocon, assisting the Sec61 protein-conducting channel by regulating signal sequence and transmembrane helix insertion in a substrate-dependent manner....
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Protein import into chloroplasts is mediated by a protein import apparatus located in the chloroplast envelope. Previous results indicate that there may be multiple import complexes in Arabidopsis. To gain further insight into the nature of this multiplicity, we analyzed the Arabidopsis ppi1 and ppi2 mutants, which are null mutants of the atToc33 and atToc159 translocon proteins, respectively. ...
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The ability of insulin to stimulate protein synthesis and cellular growth is mediated through the insulin receptor (IR), which phosphorylates Tyr residues in the insulin receptor substrate-signaling proteins (IRS-1 and IRS-2), Gab-1, and Shc. These phosphorylated substrates directly bind and activate enzymes such as phosphatidylinositol 3'-kinase (PI3K) and the guanine nucleotide exchange facto...
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Insulin has been shown to enhance the incorporation of labeled amino acids into the protein of the isolated rat diaphragm and other tissues (1, 2). The insulin stimulation is not exerted through an effect of the hormone on the transport of external amino acids to intracellular sites of protein synthesis.’ The dependency of this insulin action upon the nutritional status of the animal and a requ...
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ژورنال
عنوان ژورنال: Science Advances
سال: 2019
ISSN: 2375-2548
DOI: 10.1126/sciadv.aax0292